| Study | Formula for Predicted Mean (mm) | SD Formula | Notes | |-------|--------------------------------|------------|-------| | | ( 14.0 + 18.7 \times \textBSA ) | ( 1.89 + 1.08 \times \textBSA ) | Derived from 1526 healthy adults; widely used in adults. | | Gautier et al. (2010) | ( 13.9 + 14.6 \times \textBSA ) | ( 1.92 + 0.80 \times \textBSA ) | Pediatric & adult; used in many European centers. | | Campens et al. (2014) | ( \exp(2.69 + 0.49 \times \ln(\textBSA)) ) | ( 0.12 \times \textpredicted mean ) | All-ages, better for children and small adults. |
[ Z = \frac\textObserved aortic root diameter - \textPredicted mean diameter\textStandard deviation (SD) of predicted mean ] marfan z score
[ Z = \frac38 - 52.154.09 = \frac-14.154.09 = -3.46 ] | Study | Formula for Predicted Mean (mm)
Predicted mean = ( 14.0 + 18.7 \times 2.04 = 14.0 + 38.15 = 52.15 \text mm ) SD = ( 1.89 + 1.08 \times 2.04 = 1.89 + 2.20 = 4.09 \text mm ) | | Campens et al
Z-score -3.46 → normal (small aortic root for BSA). Not Marfan-related aortic dilatation. Revised example (pathologic): Same patient, observed root = 46 mm
